Breast Cancer and Oral Contraceptives

The risk of a woman with breast cancer depends on many factors, many of them with natural hormones. Hormonal risk factors include conditions that allow high levels of the hormone estrogen to persist for long periods, such as menstruation at an early age first (before 12), late menopause (after 55), and to have children after 30 years of age and have no children at all.

Like many of the risk factors for breast cancer associated with natural hormones, because the work of contraceptives by mouth through the manipulation of these hormones, and there was some concern that the potential effects of drugs such as oral contraceptives on the risk of breast cancer, especially if take women for many years. Introduced contraceptives by mouth in the 1960s, and sufficient time has elapsed to allow researchers to study a large number of women taking the pill for several years, beginning at an early age, and continued progress with age.
In the past 15 years, many studies examine the use of oral contraceptives as a risk factor for breast cancer has resulted in inconsistent results. While most found no overall increased risk of breast cancer associated with use of the commander, in June 1995, researchers at the National Cancer Institute (NCI) for the increased risk of breast cancer among women under the age of 35 who used oral contraceptives for a period of not less than 6 months compared with those who had never used. I also saw a little less, but the risks are still high among women between 35 and 44. In addition, his research showed an increased risk among users of long-term organized crime, especially those who had started taking the pill before the age of 18 years.
And a more comprehensive analysis, which included a study conducted in 1995 found that although there is a slightly elevated risk of breast cancer in women who were current or recent users of oral contraceptives and the risk of breast cancer once again to the normal level of 10 or more years after stop taking oral contraceptives. The results of this study is consistent with the survey in 1995.
It examines a comprehensive report on the results of a study 54 of 25 countries involved 53,297 women with breast cancer and 100,239 women without breast cancer. More than 200 researchers participated in this combination of a comprehensive analysis of the original study, which represent about 90 percent of the epidemiological studies throughout the world have investigated the possible relationship between contraceptive oral and breast cancer.
Reduction in risk after 10 years or more to be out of OCs was consistent regardless of family history of breast cancer, reproductive history, and geographical area of residence, ethnic background, and the differences in study designs, type and dose of hormones, and duration of use. This year risk reduction also applies to the age of first use, but for reasons still not understood, there was a steady increase in risk among women who had begun using the pill before the age of 20.
One aspect of the study is encouraging that the slightly elevated risk seen in each of the current users of organized crime and those who had stopped use within 10 years could not be due to a contraceptive in itself. A slightly elevated risk can arise from the hormone estrogen can promote the growth of breast cancer cells already exist, instead of its potential to initiate the changes neoplasms.
Furthermore, the observation that a slightly elevated risk of breast cancer has been seen in this study reached its peak during use, and gradually decreased after the commander of use has ceased, and returned to normal levels of risk 10 years or more after quitting, is not compatible with the normal process of carcinogenesis . Danger is the most common cancer of the peak decades after exposure, and not immediately after. Cancer in general are more likely to occur with longer and / or degree of exposure to a carcinogen. In this study, analysis, or detention or the duration of hormone use affect the results.